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For more detail on how these medicines work, see How Semaglutide Works in the Body and How Tirzepatide Works

Additional studies with different active comparators will further expand our understanding of the differences in efficacy and tolerability within this class of agents

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Their finding marked a decisive breakthrough because it challenged a long-standing belief that nerves controlled the secretion of digestive enzymes that had grown out of the work of Ivan Pavlov, the Russian physiologist who demonstrated that dogs can be conditioned to salivate by the sound of a bell (Rehfeld 2012)