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As these programs expand across indications, aligning clinical evidence, trial design, and regulatory strategy becomes just as critical as the initial innovation

Although the literature point towards aversive responses to GLP-1, some studies have still found reductions in food reward-motivated behavior by brain site-specific GLP-1R agonists using doses that were not associated with CFA and/or pica

Despite these advancements, several challenges persist

Other food options have proven helpful in keeping patients on track: fruit (due to its capacity to healthily satiate sweet cravings), protein shakes, and homemade soups have also seen an uptick in popularity, given their balanced nutritional content and convenience for those with reduced appetites