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Reduced hepatic bilirubin clearance can be due to defective (i) unconjugated bilirubin uptake and intrahepatic storage, (ii) conjugation of glucuronic acid to bilirubin (e.g., Gilbert syndrome, CriglerNajjar syndrome, LuceyDriscoll syndrome, breast milk jaundice), (iii) bilirubin excretion into bile (DubinJohnson syndrome), or (iv) conjugated bilirubin re-uptake (Rotor syndrome)
