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The advent of glucagon-like peptide-1 receptor agonists (GLP-1RA) has transformed diabetes care, not only through improvements in HbA1c and body weight, but by demonstrating a consistent reduction in major adverse cardiovascular events (MACE)

Aunque su mecanismo de accin no depende del control glucmico, deberamos tambin ampliar el concepto cardiorrenal a cardio-reno-metablico, pues estos frmacos no pierden su eficacia hipogluce miante aun en estadios avanzados de ERC a diferencia de otros grupos teraputicos

These complementary receptor actions reduce appetite and energy intake, slow gastric emptying, and improve glucose regulation, which together drive steady weight loss