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As such, there is high demand for a family of anti-obesity drugs known as glucagon-like peptide 1 receptor (GLP1R) agonists (GLP1RAs) such as semaglutide, which effectively reduce body weight and food intake in rodent models and humans 4,5
While weight loss continues initially, the body's efficiency reduces calorie burn at rest, making future weight loss harder and regain more likely after treatment stops
