how were glp 1 drugs discovered GLP-1 medications get at the heart of addiction: study – WashU Medicine Advances in GLP-1 receptor agonists:
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J Diabetes (2012) 4(2):16471

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Robert Kushner: The STEP trials were the phase three foundational clinical trials for Novo Nordisk that brought semaglutide to the market
GLP-1 may nevertheless also directly inhibit glucagon secretion, because -cell-specific GLP-1R KO mice have elevated non-fasting glucagon levels relative to wildtype controls and female -cell-specific GLP-1R KO mice are mildly glucose intolerant with increased secretion of glucagon upon peripheral administration of glucose [607]
