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2022 Jul 21;387(3):205216

Glucagon Activation Increased energy expenditure, hepatic fat oxidation, and basal metabolic rate, expanding the therapeutic mechanism beyond appetite alone

Consider requesting a slower escalation, spending six to eight weeks at each dose level before increasing

Contrave: Contrave combines two medications, naltrexone and bupropion, which work together to affect the areas of the brain that control eating behavior and appetite