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These drugs aid glycemic control through multiple mechanisms like enhancing insulin secretion, suppressing glucagon levels, and reducing appetite to induce weight loss

A relative cost of control analysis of once-weekly Semaglutide versus Exenatide extended-release, Dulaglutide and Liraglutide in the UK

While some individuals may notice an initial weight loss of 5-15 pounds within the first 4-8 weeks, others may experience a more gradual, consistent reduction in weight over a longer period

Overall, current guidelines recognize liraglutide and semaglutide as first-line pharmacotherapy options for severe adolescent obesity when combined with lifestyle therapy