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Food and Drug Administration also is investigating unconfirmed reports of suicidal thoughts or actions in people taking the GLP-1 drugs
Pre-existing thyroid disease : The SmPC notes that thyroid adverse events, including goitre, may be more frequent in patients with pre-existing thyroid disease

This precision medicine approach may facilitate the identification of subgroups most likely to benefit from GLP-1 RAs and contribute to the development of targeted interventions at the metabolic-psychiatric interface
