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On December 22, 2025, the FDA approved Novo Nordisks once-daily [...]

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Early reports suggested a possible increase in thyroid tumors

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Key pathways, including Wnt/-catenin, bone morphogenetic protein 2/Smad, phosphoinositide 3-kinase/Akt and protein kinase A, play a role in this

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Results Mean weight dropped from 133 to 87 kg by year 2, with %EWL peaking at 68% and declining to 63% by year 5

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