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Exposure to SGLT2 inhibitors from postnatal day 21 to 90, the period functionally coinciding with the late second and third trimesters of human pregnancy regarding kidney development, caused dilatation of the renal pelvis and tubules ( Table 2 )

"Fewer than one in 10 patients who could benefit from GLP-1 treatments are actually taking them," said David Ricks, CEO of Eli Lilly

Recent evidence suggests that semaglutide, like other glucagon-like peptide-1 (GLP-1) receptor agonists [11], [12], [13], [14], [15], [16], may offer additional benefits beyond glycemic control and can suppress certain harmful pathways [17], [18], [19]

doi: 10.1001/jama.2016.0287 2