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For example, Nagashima and colleagues showed that administration of active GLP-1(736) amide via osmotic minipumps for 4 weeks decreased atherosclerotic lesions and macrophage numbers in the aortic wall in Apoe / mice on high-fat diet (HFD), compared with vehicle controls (1)

A study in dogs in which berberine was administered by IV showed cardiac depression effects

Patients carrying certain GLP1R variants may achieve meaningful appetite suppression at lower doses, while others may require higher doses to trigger the same response