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tirzepatide dysesthesia In four recent placebo-controlled clinical trials, dysesthesia, an unpleasant sensation that's perceived on or under the skin, was reported as a side effect of the GLP-1 agonist semaglutide in 5-23% of recipients π§ β¨ Letβs talk about dysesthesia
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This is different from the lyophilized (freeze-dried) powder, which is stable at frozen temperatures
Treatment discontinuation (34%) was the most common censoring reason (Supplementary Table 20)

doi: 10.1001/jama.2023.24945 [DOI] [PMC free article] [PubMed] [Google Scholar] 34

A gradual dose escalation is the primary strategy used to improve tolerability and ensure you can continue with the therapy
