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Proposed mechanisms include enhanced insulinotropic activity, improved adipose tissue handling of nutrients, central effects on appetite and reward pathways, and improved tolerability or pharmacodynamic balance when combined with GLP-1 receptor agonism

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It is used to treat T2DM and obesity, improve weight loss, and reduce the risk of significant heart disease such as heart attack or stroke in some adult patients
293: E1746E1755 [DOI] [PubMed] [Google Scholar] 123.Althage MC, Ford EL, Wang S, et al
