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Semaglutide can be combined with certain supplements, but drug interactions and individual health factors require careful evaluation

The anticipated weight loss with SGLT2is is not reflected in clinical trial results
There is direct evidence comparing semaglutide to sitagliptin and dulaglutide in patients inadequately controlled on one oral antidiabetic drug (OAD), and to exenatide or insulin glargine in patients with inadequate glycemic control with one or two OADs, however data are lacking for other comparators
