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Most effects are worst during the first few weeks at each new dose level and improve significantly after 2 to 3 weeks at stable doses

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These inter-agent differences may be due to pharmacokinetic and pharmacodynamic distinctions including receptor internalization rates and secondary messenger activation 38

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It's a non-negotiable element for reproducible science

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Regardless of their characteristics, it might be reasonable to employ long-acting, sustained release formulations to maintain optimal steady-state therapeutic drug levels in light of difficulties in cognitive and motor function of patients with PD and other neurodegenerative diseases to best achieve compliance and efficacy

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