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The results of paired t-tests (the Mann-Whitney U test) for VAS appetite measurements demonstrated significant differences between groups and a clear trend toward a lower level of hunger and desire to eat, a higher level of fullness and satisfaction, as well as higher satiety, in participants consuming PE with PE juice

This dual mechanism may contribute to greater reductions in HbA1c and body weight in clinical trials

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Similarly, some oral diabetes medications like sulfonylureas can increase low blood sugar risk when combined with semaglutide's appetite-suppressing effects, requiring close monitoring or dose adjustments