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PPARs play a crucial role in the regulation of mitochondrial function [13]
The included studies can be seen in Table 1
Glucagon-Like Peptide-1 Receptor Agonist (GLP-1 RA) and dual agonist clinical guidance Herts and West Essex ICB

The medications have complementary effects on glucose control, and metformin has a long safety track record in combination with GLP-1 based agents
