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The turn away from homecooked meals is fueling concerns about nutrition, concerns that are only underlined by manufacturers marketing of processed foods as fortified. The Philippines Department of Health promotes the local production of food supplements to counter malnutrition (DOH 2017), and pharmaceutical companies advertise supplements to boost health and mitigate the stresses of everyday urban living

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Furthermore, a study revealed that liver-specific Zip8 KO mice exhibited significant decreases in systemic Mn levels under both Mn-rich and Mn-depleted conditions, indicating that hepatic ZIP8 mediates Mn reabsorption from bile to help maintain systemic homeostasis (Powers et al., 2023)