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Primary progressive multiple sclerosis is defined as progressive symptoms with disability progression over at least 12 months, without clinical relapse and having at least two of the following: one or more characteristic brain lesions, two or more characteristic spine lesions, or oligoclonal bands in the CSF (101)

I NOTICED MY love handles before I even knew the term love handles. Back in high school, after my freshman year, I got absurdly leanunder one hundred pounds

However, these mechanisms are not flawless

Specifically, methylated cytosines are recognized by DNA methyl-binding proteins (MBPs) that repress gene transcription by preventing the interaction of transcription factors with the promoter (62)