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Thats exactly why Novo Nordisk combined cagrilintide with semaglutide in CagriSemathe idea is that hitting both the amylin and GLP-1 pathways together could produce greater effects than either one alone

Gonadotrophins inhibit the expression of insulin-like growth factor binding protein-related protein-2 mRNA in cultured human granulosa-luteal cells

10.1186/s12943-018-0864-3 [DOI] [PMC free article] [PubMed] [Google Scholar] 89.Erlebacher A

If persistent nausea remains at 12mg after 4+ weeks, some researchers step back to a 9mg dose, which research showed produces nearly comparable weight loss with improved tolerability