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Description
According to a study conducted in Mexico on 350 ESBL-producing E
Cereblon-based PROTACs: factors influencing efficacy The efficacy of cereblon-based PROTACs depends directly on the absence of mutations that interfere with the binding of the degrader to the protein, or indirectly, on mutations that interfere with the formation of the E3 ubiquitin ligase CRL4 CRBN complex, such as mutations that interfere with the binding between cereblon and the DDB1 protein
Middle-income countries exhibit a high prevalence, with a rate of 18.6% [11]
Callahan, J
