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Primarily, these cells express very low levels of key antioxidant enzymes, including catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD), which are primary defense mechanisms against reactive oxygen species (ROS) [81]
a reduction in Nrf2 significantly decreases HO-1 expression
6 A previous in vivo study 78 aimed to evaluate the effects of NAC in a murine experimental model of osteoarthritis
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