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When irradiated with near-infrared (NIR) light, AuNPs undergo localized surface plasmon resonance, generating hyperthermia (4245 C) that selectively ablates tumor cells while sparing healthy tissues [130, 131]
In this context, activation-induced mitochondrial reactive oxygen species (mROS) production caused a rapid, extensive DNA damage response and consequently PARP1 activation with associated NAD + consumption
Joint Bone Spine 86(3):301307
Over time, this stress can impact the delicate structures of the kidneys, including the filters known as glomeruli
