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Intramuscular is the minority case, discussed mainly for higher-volume compounds like NAD+

The ensuing cytochrome C efflux activates caspase-9 and caspase-3, while ROS-induced DNA damage stabilizes p53, shifts the Bax/Bcl-2 balance toward apoptosis [65], and upregulates Fas/FasL signaling [66]

Kostrubsky VE, Strom SC, Wood SG, Wrighton SA, Sinclair PR, Sinclair JF: Ethanol and isopentanol increase CYP3A and CYP2E in primary cultures of human hepatocytes

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