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The solubility of unionised form of the drug is known as the intrinsic solubility of the drug
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It is found in high concentrations in the liver and other tissues, where it acts as a potent detoxifier and protector against toxic injury
Given that complexity and importance have been identified in lysosomal lipid peroxidation as a mediator of LCD [132], additional work are required to elucidate how lipid peroxidation affect the LMP, and synergistic or complementary functions involving these LCD pathways need to be further assessed
