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The gradual increase in strength over at least a 17-week period is designed to minimise the impact of side effects such as constipation and diarrhoea

Metabolic modulation of the right ventricle and pulmonary circulation in pulmonary arterial hypertension: an interventional study using a Glucagon-like-peptide-1 (GLP-1) agonist

However, persistent or severe symptoms may indicate a need to adjust the dose or timing

Gradual weight reduction of several pounds over a few weeks is expected and healthy
