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GLUCAGON-LIKE PEPTIDE-1 GLP-1 is a peptide hormone secreted by intestinal enteroendocrine L-cells, specific neurons of the solitary tract in the brainstem and some -cells in the pancreas [28]
Activation of FXR by the gut microbiota was shown to reduce the expression levels of most bile acid synthesis enzymes and inhibit the expression of gluconeogenic genes (201, 202), thereby linking the intestinal microbiota to the regulation of bile acids and metabolic homeostasis
Simon-Szab, L., Kokas, M., Mandl, J., Kri, G
