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Follistatin is a protein that binds to MSTN and activin, thereby preventing these ligands from interacting with their receptors, ActRIIA/B.[13] This property has been utilized in gene therapy to treat degenerative muscle diseases.[84] The application of this therapy is not limited to muscle-related diseases

GIPs action to augment splanchnic blood flow, potentially affecting nutrient uptake and its involvement in adipose tissue metabolism and suggested central affects in the regulation of appetite as seen in animal models, all remain to be further explored in humans

However, as with other peptide systems discussed in this review, such variability often reflects limitations in measurement, context, or study design rather than the absence of biological relevance