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For Ozempic (semaglutide for type 2 diabetes), headache incidence varies across the SUSTAIN clinical trials

Growth hormone elevation from sermorelin can impair insulin sensitivity in some patients, potentially opposing semaglutide's insulin-sensitizing and appetite-suppressing benefits

This context may help tailor starting dose, titration pace, and medication choicebut does not guarantee outcomes

These individuals often show blunted GLP-1 responses after meals, suggesting that improving baseline metabolic health can restore more robust GLP-1 signaling over time (Huber et al., 2024)
